Obviously, a pair of 7500's will be nowhere near their limits in handling the load in question. As for cross-talk between channels, I've not heard of that being a problem when the 7500 is used under normal circumstances. if you were concerned, you could always make use of the separate transformers - put the woofers on one transformer and the mid & tweeter on the other (Svet's pictures of the 7500 show you which channels are connected to which transformer). I'd consider that to be overkill, but it could be an extra bit of peace of mind...