I just bought the Harmony One last week after nearly 2 years of owning this set up. This remote has tied it all together. It even has all the functions for a Sirius Sportster Radio which I wasn't expecting. I am satisfied with this purchase.

I concur with WildWolf that the programming is a no brainer.
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Living Room: Outlaw 990-7125. 3 Outlaw LCR's (FL-C-FR). 2 Outlaw Surrounds. 2 Outlaw BLS in the rear. Outlaw LFM-1 Plus Subwoofer. TCL 65 inch Roku TV. OPPO BDP-83.

Bedroom: Marantz Cinema 70S. Aperion's all the way around. Apple TV. HTPC built from scratch.