I haven't used any Harmony remotes, but I've still got very URC remote I've bought since 2003. The MX-500 in particular has been dropped countless times, knocked off furniture by cats, spit up on by an infant, and splashed with water in the kitchen over the last 5.5 years. Aside from the backlight not working anymore and some wear on the case, it works as good as the day I unboxed it. The MX-700 looks brand new after 3.5 years.