I have the Harmony ONE and it is without a doubt the best item I purchased when I upgraded to the 990/7125 combo. It is easy to program and can run any macro you can think of to make it do. It also error corrects by asking you questions about the system. I labeled each of my components the same way I named them in the remote and I haven't gotten any more of those stressed phone calls at work about why something isn't working. It takes about 2 minutes to explain to someone how to use it and the rest is in the software. Don't struggle with the supplied remote and trying to learn it a bunch of codes. The Harmony website (Logitech) has all of the codes for all of your equipment, and it all works flawlessly. You actually program the remote on line and the website saves your settings. You can edit any time you want and add or subtract equipment. It will be the last remore you ever have to buy. You can even set it up to control multiple systems if you wanted.
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Music system
Model 990/7500/Magnepan 1.6 QRs/Technics SL1200 MK2/Aperion S-12 Subwoofer/OWA3/Sony NS75H DVD
APC H15 Power Conditioner
TV System
Large Advent Loudspeakers/ Polk center/Monoprice surrounds/Panasonic Viera 42 inch/Onkyo HT-RC260/Sony BDP S590/Directv
Home Theater System
Onkyo PR-SC886/Outlaw 7125 Klipsch RF-82 L/R,RC-62 center, RB-35 SR/SL, BENQ HT1075, Outlaw LFM1-EX/OPPO BDP-83/Directv
Harmony ONE
Blue Jeans and Monoprice interconnects
APC H15 Power Conditioner