Allowing for the fact that ...
1) the 990 update software is not officially supported for use on the Vista OS,
2) your experience my be different from mine for various reasons,
... In my experience it is possible to successfully perform the upgrade to version 3.11 using a USB cable and a PC with the Vista Home Premium operating system.* As such, I believe the newest upgrade will also work via Vista.
Other than clicking the 'update' button (later in the process) as mahansm** mentions, I had only one thing to contend with that was not already covered in the instructions. When it was time for the installation software to find the .inf file, I could not successfully find the folder containing the file by merely using the 'browse' button in the software installation prompt window. In a separate window I opened, I checked to make sure I could view hidden folders and navigated manually to the correct folder. After finding the proper folder on my own, I merely copied the location character string from my separate window and pasted it into the installation software prompt window. I then closed my separate window and continued with the installation process.
Edit: *The PC was Intel Core 2 Duo based, Vista running 32-bit, not 64.
**Posted by mahansm: The omission was that the instructions did not say to press the "upgrade" button when it was obvious that it was the next step. Separate message sent to tech support, so the instructions should be amended shortly.