I have been a URC fan for years. I did get a Harmony at one time but did not like the button layout plus the buttons were too small for my big mitts.

As gonk said the URC is a bit more flexible as you set up the macro's your self.
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Outlaw 990/7700
SVS 20-39 PC +
SVS MTS-01 towers, MCS-01 center, MBS-01 surrounds
Behringer A500
Samsung PN58A650, DirecTV HR-20 700
Sony CDP-545, Phillips CDR 765
Oppo BDP-93, Panasonic DMR E515
Technics SL-DL5
Squeezebox 3
Remote Harmony One