I would say that if you have two subs already, setting them up in stereo is worth a try. If you have to buy another sub, I would say it would probably not be worth it unless you already wanted to buy the extra sub. With two subs, you can always set them up conventionally if you find that running them in stereo doesn't work for you. The nice thing about the stereo sub setup is that if you already have the two subs, there is really no cost to do it other than some extra interconnects.