My Harmony one allows me to have multiple startup versions on its display screen such that when I want to watch a movie via my OPPO it just starts the receiver with the OPPO as the input and starts the OPPO and the projector at the same time. It's all in how you program the remote via the Logitech site. Newer versions of the device may be different but the one I have is capable of controlling more than one system depending on how you program it and what your are pointing it at.
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Music system
Model 990/7500/Magnepan 1.6 QRs/Technics SL1200 MK2/Aperion S-12 Subwoofer/OWA3/Sony NS75H DVD
APC H15 Power Conditioner

TV System
Large Advent Loudspeakers/ Polk center/Monoprice surrounds/Panasonic Viera 42 inch/Onkyo HT-RC260/Sony BDP S590/Directv


Home Theater System
Onkyo PR-SC886/Outlaw 7125 Klipsch RF-82 L/R,RC-62 center, RB-35 SR/SL, BENQ HT1075, Outlaw LFM1-EX/OPPO BDP-83/Directv
Harmony ONE
Blue Jeans and Monoprice interconnects
APC H15 Power Conditioner