I no longer use my Harmony One with my 990 but... when you set up the remote with the logitech software you can tell the remote which pieces of the processors remote function to duplicate. I selected all when I set up my devices and the Harmony has screens for every command I can perform in my 990, Onkyo 886, OPPO BDP-83, iPod, Directv receiver and my TV. It is a little cumbersome but the screens are there. Based on that I think you can tell the Harmony to do anything the remote will do.
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Music system
Model 990/7500/Magnepan 1.6 QRs/Technics SL1200 MK2/Aperion S-12 Subwoofer/OWA3/Sony NS75H DVD
APC H15 Power Conditioner

TV System
Large Advent Loudspeakers/ Polk center/Monoprice surrounds/Panasonic Viera 42 inch/Onkyo HT-RC260/Sony BDP S590/Directv


Home Theater System
Onkyo PR-SC886/Outlaw 7125 Klipsch RF-82 L/R,RC-62 center, RB-35 SR/SL, BENQ HT1075, Outlaw LFM1-EX/OPPO BDP-83/Directv
Harmony ONE
Blue Jeans and Monoprice interconnects
APC H15 Power Conditioner