I have my MX500 M-macros set for turning the lights down M1, truning the sound down M2, and M3 is used to trun on the 2nd zone (not using) which activates the the 2nd Panamax. The 10 device macros are usually reserved for turning on that specific component. For example, the TV device button will switch the component inputs to the proper input, but if I hold the button down for more than 2 seconds it will power on/off the TV. I would also recommend the IRClone-MX. it's been a great help in getting everything working correctly.