It works from a Mac Mini. I hook it up as a media center at times, playing downloaded HD video content from it with the DVI output going to the HDTV and the toslink output going to the 990. But before I got the proper mini-toslink cable, it had the audio going to the 990 via USB, and the computer's audio out set to go via USB. Worked great. Played my entire iTunes library just fine as well.

Hope that helps answer your question.