I think I may have this issue also. Just sent in the support request. I only have three speakers hooked up right now, FR, FL and center. Just before the speaker goes out I hear a click which sounds like the click you hear when you put the unit in standby or power on from standby. After a while it clicks again and the speaker starts working again.

Has anyone had this repair done? How was the result?
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Desperado - 1050 Owner - Reviews - Harmony SST-659 Remote