Even large mains that can supposedly handle the full 20hz to 20khz frequency, in my opinion, should still be set to small.
It will clear up the sound a bit and your amp/receiver won't have to dig as deep, which will keep everything running cleaner.
But, I went a while without a LFE sub and Yes, I set them to large. Movies can be a tad boring when theres no bass whatsoever.
You probably won't harm your speakers unless you have weak amplification, and start clipping.
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Play it LoUd!!
[This message has been edited by SpOoNmAn (edited September 26, 2003).]