Me three.

I'm with AvFan and Gonk. I have a Harmony 880 and now that I've I got it set up exactly how I want it (took a couple of hours), it's awesome. I consolidated six remotes and five activities and personally felt no burning need for custom macros so the 880 suited me well. My wife also quickly came to the conclusion that this was one of the best upgrades ever.
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Outlaw 976, Outlaw 7700, Pro-Ject Phono Box S
Sonus Faber Domus Grand Piano (F&C), Niles HDFX (Surr. & Rear Surr.), Outlaw LFM-1 Plus, Velodyne SMS-1
Sonos multi room audio
Video: Sony KDL-46V2500, OPPO BDP-103, TiVo Premiere XL4
2-channel: Outlaw RR2150, SF Concerto Home, Outlaw LFM-2