I got the Harmony One today setup is pretty easy, and the software is great. Not as well built as the MX models but it will do. And it has all the codes for everything I own, including my Sangean WI FI radio...
I just went from using URC remotes (MX500, 700, 850) for years to a Harmony One. Much better software and the database for codes is fantastic.
The biggest downside for the URC remotes was keeping the database up to date and their insane policy about only allowing "professional" to get access to their software. I loved my URC remotes but time to move on.
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Outlaw 990/7700
SVS 20-39 PC +
SVS MTS-01 towers, MCS-01 center, MBS-01 surrounds
Behringer A500
Samsung PN58A650, DirecTV HR-20 700
Sony CDP-545, Phillips CDR 765
Oppo BDP-93, Panasonic DMR E515
Technics SL-DL5
Squeezebox 3
Remote Harmony One