There are several different universal remotes available which are reprogrammable when you change out equipment. I use the Harmony ONE from Logitech. It is easy to program and has a intuitive touch screen with your various activities on it so you can select what you want the system to do (Watch TV, Watch a BluRay, Listen to Radio). It is programmable for almost any device either over the internet or by learning from your old remote. You can even use it to control multiple systems if you want.
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Music system
Model 990/7500/Magnepan 1.6 QRs/Technics SL1200 MK2/Aperion S-12 Subwoofer/OWA3/Sony NS75H DVD
APC H15 Power Conditioner
TV System
Large Advent Loudspeakers/ Polk center/Monoprice surrounds/Panasonic Viera 42 inch/Onkyo HT-RC260/Sony BDP S590/Directv
Home Theater System
Onkyo PR-SC886/Outlaw 7125 Klipsch RF-82 L/R,RC-62 center, RB-35 SR/SL, BENQ HT1075, Outlaw LFM1-EX/OPPO BDP-83/Directv
Harmony ONE
Blue Jeans and Monoprice interconnects
APC H15 Power Conditioner