You can, and you really wouldn't need to have a Squeezebox at work. Squeezebox is powered by software called SlimServer, that runs on your home PC. In order to access from another PC, you need to:

1) Open up the appropriate ports on your home router and forward them to the PC that SlimServer is installed on (as well as opening them up in any firewall software you are running);

2) Get a static IP or easier, get a free account at DynDNS.org or no-ip.com or similar (my router and I think a lot of Linksys routers in general have built in support for DynDNS).

Then at work, open WinAmp or another software player, and open the URL:

http://:9000/stream.mp3

Then open a web browser and open the URL:

http://:9000

which gives you the SlimServer GUI.

There's a couple other niceties, like for instance you'll want to specify that for that player (meaning your work PC) you want everything converted to MP3 (streaming FLAC or WAV would probably be too bandwidth-intensive, resulting in dropouts and a pissed-off sysadmin), but that's the gist of it. Instructions used to be posted at SlimDevices somewhere, but I can't find them at the moment.

Again, you don't have to have a Squeezebox at home to try this, just SlimServer running on your PC.

Ed