I have tried bi-wiring on numerous systems. In most cases there was little to no difference. However, in one case it did make a difference and I preferred the biwired combo. This is in my current den music system. I have a pair of ASL Wave-DT's hooked to a pair of Wharfedale Anniversary 7.2. I am also using a Canare shotgun configuration of Canare 4S11 for the bottom end and Canare 4s8 for the top end. I originally utilized two runs of 4s11, but the top end seemed muted, not rolled off, just muted. That cleared up with the substitution of the 4s8. I like experimenting and have gone back to single runs on other systems. YMMV.