The wire is more practical for me because my system (except for the mains) are built into the wall and the speaker wires can be seen. I can tell you that the Canare wire does not sound any worse than biwiring with the Home Depot cable. The Canare may actually be better but it hard to say w/o being able to switch between them. I have fairly new Quad 22l mains and they are sounding better with the more hours I put on them as well. If your looking to inexpensively bi-wire you speakers and you want 1 cable than can do it for you Canare is the best I found. I suppose you could make your own biwire speaker for less but that takes time. Hope this helps.