The 750 is a universal 5-disc changer. If you're looking for 7.1 from a SACD or DVD-Audio, you're out of luck. No hi-res releases feature those channels. Your best bet is to connect the analog outs to the direct ins on the 2500 and let the receiver do the processing for hi-res formats. Otherwise, use the digital connection.
The 2500 is a very slick receiver by the way. It would be cool of Outlaw to check out the features it offers to see how they could incorporate similiar features on the 1070. Namely, some of the YPAO ability.