I've not spent much time with the Harmony stuff - some early research into their programming interface left me a little disinterested (prefer the degree of direct control offered by the URC stuff, which is coincidently part of the reason I was not real keen on URC's MX-810).

Remote ergonomics are challenging - similar to designing a really useful user interface or writing a really useful manual. I think that's one reason the companies like URC, Harmony, and UEI do a better job with designing remotes than companies like Denon that develop their own.