I've always been of the opinion that being able to distinguish between cables (or electronics for that matter) is dependent upon the quality of the other components in the system. If you've got speakers and components of average performance, you may not be able to hear any difference between one set of speaker cables or another. In my experience, I have been able to tell differences in speaker cables and interconnects. Sometimes, differences are perceived as better, just because it's different. What matters most is what sounds right to you....if you can accomplish this with Home Depot speaker cables, save your money and buy some DVD/CD's!! If you try some more expensive/exotic cables and your listening experience improves, then it's money well spent. BTW, I use Outlaw Interconnects and Tara Labs Prism Bi-Wire speaker cables.