I see where the harmony remote would work for the squeeze box 3; however, the duet has a remote with an LCD screed instead of the display on the main unit itself. The duet remote has the art cover work, artist info and song list. The Harmony One may be capable of displaying this info, not sure. Squeeze Box definitely has solid products; I just like the idea of having the display on my large screen HDTV. If I were using for music only I would probably get the duet.